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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicactivation, well known for its role in the immune surveillance against tumor and pathogen-infected cellsIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell phenotype immune activation immune tolerance liver diseases

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract:

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigensNatural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolicIn this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitiskiller T cells during the progression of liver diseases, which might be caused by changes in naturalkiller T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer

Keywords： natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract: Compelling evidence suggests that NK cells play a critical role in the immune function of the liver andTo obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizescurrent knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies

Keywords： natural killer cell hepatocellular carcinoma immunotherapy

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Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: Natural killer (NK) cells, a type of cytotoxic lymphocytes, can infiltrate into ischemic brain and exacerbateThis study investigated the effects of ASIV on post-ischemic brain infiltration and activation of NK cellsAbundant NK cells infiltrated into the ischemic hemisphere on day 1 after brain ischemia, and this infiltration

Keywords： astragaloside IV brain ischemia natural killer cells histone deacetylase nuclear factor-κB

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract:

Natural killer (NK) cells are considered to be critical players in anticancer immunity.However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells, expanding allogeneic NK cells, usage of stable allogeneic NK cell lines and genetically modifying freshNK cells or NK cell lines.In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell natural killer cell line tumor immunotherapy genetic modification

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidlyand directly kill transformed cells in the absence of antigen presensitization.Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK celllines, have been used for producing NK cells.In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did

Keywords： natural killer cells immunotherapy adoptive transfer genetic modification immune checkpoint inhibitor

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer(BAK) cells, and the effect of anticancer BAK cells was studied.BAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cellsThe result of LDH release assay showed that the antitumor activity of BAK cells stimulated by Recombinant

Keywords： Urology powerful 2b-BCG Tianjin institute wild-type

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: During natural infection, viral replication is initially controlled by innate immunity before adaptiveimmune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery.Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8⁺ and CD4⁺ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza innate T cells CD4⁺ and CD8⁺ T cells vaccination

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract:

γδ T cells display unique developmental, distributional, and functional patterns and canγδ T cells are enriched in the liver and exhibit liver-specific features.In this study, we review the properties of hepatic γδ T cells and summarize the roles ofγδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in liver diseases

Keywords： γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1, Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract:

Natural killer (NK) cells are key innate immune cells that provide the first line of defense againstAlthough NK cells can discriminate between "self" and "non-self," recognize abnormalcells, and eliminate transformed cells and malignancies in real time, tumors develop several strategiesNK cells, umbilical cord blood (UCB) or induced pluripotent stem cell (iPSC)-derived NK cells, memory-likeNK cells, and NK cell line NK-92 cells, for the treatment of different types of tumors.

Keywords： Natural killer cell Immunotherapy Cancer Clinical trial Chimeric antigen receptor

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New nanostructured sorbents for desulfurization of natural gas

Lifeng WANG, Ralph T. YANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 1, Pages 8-19 doi: 10.1007/s11705-014-1411-4

Abstract: Desulfurization of natural gas is achieved commercially by absorption with liquid amine solutions.

Keywords： desulfurization natural gas desulfurization hydrogen sulfide sorbent amine-silica sorbent

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapyThe low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT).165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cellsTCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered Tcells (TCR-Ts) in terms of interferon-g and granzyme B production

Keywords： cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblasticHowever, CAR T cells have achieved minimal success against solid malignancies because of the additionalMobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticthe immune response in solid malignancies, especially with CAR T cells acting as cellular carriers toFinally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance

Keywords： CAR T cells immunoregulatory molecules endogenous immune response solid malignancies

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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1, Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract:

Cancer is a potentially life-threatening disease characterized by the immortalization of tumor cellsRegulatory T cells (Tregs) are a subgroup of suppressive CD4+ T cells that play a vital role in the maintenanceopportunities for improving antitumor efficiency in combination with other therapeutics (e.g., Car-T-based

Keywords： Regulatory T cells Cancer Immunotherapy

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cell, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells hematological malignancies review